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Daily dose may be gradually increased to 0.7mg/kg depending on tolerance of the patient. Considering the verylimited or no binding of fosfomycin to plasma proteins, this would indicate that theaverage concentration bound to various components of bone tissue is lower than or sim-ilar to the interstitial fluid concentrations. The duration of action of zileutonis short and it has hepatotoxic potential. Demy-elinating neuropathies may be responsive to plasmaexchange or intravenous immunoglobulin.
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